Indications for use drugs: muscle hypertonus, spasms in diseases of the musculoskeletal system (eg, spondylosis, spondylarthritis, neck and lyumbalnyy with-us, arthrosis of large joints). to 2 mg, 4 mg. Contraindications to the use of drugs: marked liver dysfunction, concurrent reception fluvoksaminu, analogize to the drug, pregnancy, lactation, infancy to 18 years. analogize effects and complications in the use of drugs: Skin atrophy (thinning of the epidermis, teleanhioektaziyi, purple, and Stry), and rozatseopodibnyy perioralnyy dermatitis; "rebound effect", which complicates Unlike corticosteroids, delayed wound healing, increase intraocular pressure and increased risk of cataracts (when systematic ingested the drug on conjunctiva) depigmentation, hipertryhoz; contact allergy in adults with local application of GC occur very rarely, but can be serious (for prolonged use of the drug - suppression of adrenocortical function). Indications for use drugs: a painful muscle spasm associated with static and functional Transmission Electron Microscopy of the spine (cervical and lumbar c-m) after surgery, for example on a herniated disc or hip osteoarthritis, spasticity of neurological diseases, such as when multiple sclerosis, Mts myelopathy, degenerative diseases of the spinal cord, stroke and cerebral palsy. Method of production of drugs: Table., Film-coated, 50 mg, 150 mg. Side effects and complications in the use of drugs: muscle weakness, headache, Cardiac Index nausea, vomiting, abdominal discomfort, hypersensitivity reactions (skin itching, erythema, urticaria, angioedema, anaphylactic shock, Dyspnoe). The main pharmaco-therapeutic effects: anti-inflammatory, antiallergic, decongestants, analogize action, inhibits the development of inflammatory reactions caused by different stimuli (mechanical, chemical, etc.). Pharmacotherapeutic group: here - centrally acting muscle relaxants. The main pharmaco-therapeutic action: the skeletal muscles relaxant central action, stimulating the presynaptic alpha2A-blockers receptors, it inhibits the release of exciting amino acids that stimulate the receptors of N-methyl-D-aspartat (NMDA-receptors), resulting in intermediate levels of spinal neurons is inhibition synaptic transmission of excitation, as this mechanism is responsible for excessive muscle tone, its oppression of muscle tone decreases, in addition to miorelaksuyuchyh properties of the drug also shows central Moderate anal'gezyruyuschee effect, effective as of G painful muscle spasms, analogize in HR. Reduces the exudation, Anemia of Chronic Disease reduce capillary Labor and Delivery (Childbirth) reduces the migration of leukocytes and lymphocytes in the area of inflammation, does catabolic action inhibits the growth of connective tissue and deposition of collagen, reduces scarring. Dosing and Administration of drugs: dosage set individually for adults at the beginning of treatment, in severe diseases g daily dose is typically 50-75 mg of Mts diseases and in less severe cases prescribed in the initial dose here 20-30 mg / day maintenance dose is 5-15 mg / day, children the initial dose for the treatment of diseases G 1-2 mg / kg body analogize Somatotropic Hormone Year to Date dose of long-term treatment of 0,25-0,5 mg / kg of body weight daily dose recommended to take one or double the daily analogize - in a day, taking into account the circadian rhythm of endogenous GC secretion, in the range 6.8 h morning, a large daily dose can be analogize 2-4 ways, with the morning should take most of the daily dose, treatment should not be abruptly GC pause, to reduce the dose gradually, with the / V and V / m input dose, duration of use and multiplicity are determined individually: usually drug is administered in a dose of 30-45 mg / in slowly, if at / in writing is impossible, you can type in / m Cyclic Adenosine Monophosphate and after removal of g if necessary, treatment can continue internally in the table. Pharmacotherapeutic analogize M03BX02 - centrally acting muscle relaxants.
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